Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.74 |
| ▸ | FLT1 | P17948 | 6/20 | 0.74 |
| ▸ | FLT4 | P35916 | 6/20 | 0.74 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7551698 | 0.94 | KDR (0.73) | KDRFLT1FLT4CYP2A6TDP2 | |
| SCHEMBL7553990 | 0.93 | KDR (0.74) | KDRFLT1FLT4CYP2A6NFATC1 | |
| SCHEMBL7549411 | 0.88 | KDR (0.58) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7555272 | 0.87 | KDR (0.55) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7990322 | 0.86 | KDR (0.73) | KDRFLT1FLT4CYP2A6NFATC1 | |
| SCHEMBL7554600 | 0.86 | KDR (0.54) | KDRFLT1FLT4SMYD2DRD2 | |
| SCHEMBL7554703 | 0.85 | KDR (1.00) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7557466 | 0.83 | KDR (0.73) | KDRFLT1FLT4CYP2A6TDP2 | |
| SCHEMBL7549476 | 0.83 | KDR (0.65) | KDRFLT1FLT4GSK3BSMYD2 | |
| SCHEMBL7548335 | 0.83 | KDR (0.51) | KDRFLT1FLT4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |