Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.73 |
| ▸ | FLT1 | P17948 | 5/20 | 0.73 |
| ▸ | FLT4 | P35916 | 5/20 | 0.73 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7551698 | 0.92 | KDR (0.73) | KDRFLT1FLT4CYP2A6 | |
| SCHEMBL7986909 | 0.88 | KDR (0.57) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7990426 | 0.87 | KDR (0.54) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7553990 | 0.86 | KDR (0.74) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7987972 | 0.86 | KDR (0.74) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7994055 | 0.86 | KDR (0.56) | KDRFLT1FLT4CYP2A6 | |
| SCHEMBL7986598 | 0.86 | KDR (0.53) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7506453 | 0.85 | KDR (1.00) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7513681 | 0.83 | KDR (0.65) | KDRFLT1FLT4CNR1CNR2 | |
| SCHEMBL7994332 | 0.83 | KDR (0.50) | KDRFLT1FLT4GSK3BCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |