Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976514 | 0.96 | TAS1R3 (0.52) | TAS1R3TAS1R1MAPK9KMT2APTGS1 | |
| SCHEMBL7986479 | 0.91 | TAS1R3 (0.50) | TAS1R3TAS1R1MAPK9KMT2APTGS1 | |
| SCHEMBL7975966 | 0.88 | PTGS1 (0.56) | TAS1R3TAS1R1PTGS1PTGS2TSHR | |
| SCHEMBL7976072 | 0.85 | MAPK9 (0.52) | TAS1R3TAS1R1MAPK9KMT2APTGS1 | |
| SCHEMBL9440379 | 0.84 | MAPK9 (0.59) | TAS1R3TAS1R1MAPK9KMT2APTGS1 | |
| SCHEMBL8393098 | 0.83 | TAS1R3 (0.45) | TAS1R3TAS1R1KMT2APTGS1TSHR | |
| SCHEMBL7986653 | 0.80 | PTGS1 (0.51) | TAS1R3TAS1R1MAPK9KMT2APTGS1 | |
| SCHEMBL7988098 | 0.79 | MAPK9 (0.49) | MAPK9KMT2APTGS1PTGS2HPGD | |
| SCHEMBL7989783 | 0.79 | MAPK9 (0.51) | MAPK9KMT2APTGS1PTGS2HPGD | |
| SCHEMBL530292 | 0.78 | TAS1R3 (0.53) | TAS1R3TAS1R1KMT2ATSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |