Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 8/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988111 | 0.76 | CYP19A1 (0.51) | HPGDPDCD1CD274MAPTPTGDR2 | |
| SCHEMBL7970029 | 0.76 | FNTA (0.43) | PDCD1CD274PTGDR2 | |
| SCHEMBL7984618 | 0.75 | FNTA (0.41) | PTGDR2 | |
| SCHEMBL11592124 | 0.74 | MGLL (0.47) | HPGDMAPTCYP1A2CYP2C19LMNA | |
| SCHEMBL7970481 | 0.72 | MAPT (0.61) | HPGDMAPTCYP1A2CYP2C19TDP1 | |
| SCHEMBL21884592 | 0.69 | HPGD (0.58) | HPGDMAPTTDP1LMNAXDH | |
| SCHEMBL13063635 | 0.69 | ALDH1A1 (0.54) | HPGDMAPTCYP1A2TDP1 | |
| SCHEMBL506308 | 0.69 | SLC6A2 (0.53) | MGLL | |
| SCHEMBL8917849 | 0.68 | ALDH1A1 (0.56) | HPGDMAPTCYP1A2TDP1THRB | |
| SCHEMBL10594198 | 0.68 | KDM4E (0.49) | HPGDIRAK4MAPTCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297239-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2001-10-02 | — | — | US | disclosed |
| EP-1021188-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999017777-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-04-15 | — | — | WO | disclosed |