Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 3/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL798853 | 0.89 | LMNA (0.62) | LMNAL3MBTL1TSHRKCNH2ALDH1A1 | |
| SCHEMBL31039336 | 0.79 | LMNA (0.51) | LMNAL3MBTL1KCNH2WDR5 | |
| SCHEMBL21712010 | 0.78 | LMNA (0.50) | LMNAL3MBTL1WDR5GRM2 | |
| SCHEMBL31270697 | 0.75 | LMNA (0.74) | LMNAL3MBTL1KCNH2ALDH1A1POLB | |
| SCHEMBL21712022 | 0.75 | WDR5 (0.47) | LMNAL3MBTL1WDR5 | |
| SCHEMBL277927 | 0.74 | LMNA (0.64) | LMNAL3MBTL1TSHRKCNH2ALDH1A1 | |
| SCHEMBL2950629 | 0.73 | LMNA (0.71) | LMNAL3MBTL1KCNH2ALDH1A1POLB | |
| SCHEMBL12291554 | 0.72 | MAPKAPK2 (0.39) | LMNAL3MBTL1TSHRWDR5 | |
| SCHEMBL20097939 | 0.71 | TSHR (0.71) | LMNAL3MBTL1TSHRKCNH2ALDH1A1 | |
| SCHEMBL81625 | 0.71 | LMNA (0.63) | LMNAL3MBTL1ALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |