Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 17/20 | 0.73 |
| ▸ | LTB4R2 | Q9NPC1 | 17/20 | 0.73 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988639 | 1.00 | LTB4R (0.73) | LTB4RLTB4R2NR4A2NPC1RAB9A | |
| SCHEMBL7988633 | 1.00 | LTB4R (0.73) | LTB4RLTB4R2NR4A2NPC1RAB9A | |
| SCHEMBL7990405 | 0.88 | LTB4R (0.73) | LTB4RLTB4R2MAOB | |
| SCHEMBL7990401 | 0.88 | LTB4R (0.73) | LTB4RLTB4R2MAOB | |
| SCHEMBL7990403 | 0.88 | LTB4R (0.73) | LTB4RLTB4R2MAOB | |
| SCHEMBL7990284 | 0.86 | LTB4R (0.71) | LTB4RLTB4R2MAOB | |
| SCHEMBL7990289 | 0.86 | LTB4R (0.71) | LTB4RLTB4R2MAOB | |
| SCHEMBL7989763 | 0.86 | LTB4R (0.71) | LTB4RLTB4R2MAOB | |
| SCHEMBL7990179 | 0.84 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL7990177 | 0.84 | LTB4R (1.00) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291530-B1 | Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity | NOVARTIS AG (CH) | 2001-09-18 | — | — | US | disclosed |
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |