Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 18/20 | 0.73 |
| ▸ | LTB4R2 | Q9NPC1 | 18/20 | 0.73 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | GCK | P35557 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990401 | 1.00 | LTB4R (0.73) | LTB4RLTB4R2MAOBRARARARB | |
| SCHEMBL7990405 | 1.00 | LTB4R (0.73) | LTB4RLTB4R2MAOBRARARARB | |
| SCHEMBL7994001 | 0.89 | LTB4R (0.72) | LTB4RLTB4R2 | |
| SCHEMBL7994009 | 0.89 | LTB4R (0.72) | LTB4RLTB4R2 | |
| SCHEMBL7994006 | 0.89 | LTB4R (0.72) | LTB4RLTB4R2 | |
| SCHEMBL7988629 | 0.88 | LTB4R (0.73) | LTB4RLTB4R2MAOB | |
| SCHEMBL7988639 | 0.88 | LTB4R (0.73) | LTB4RLTB4R2MAOB | |
| SCHEMBL7988633 | 0.88 | LTB4R (0.73) | LTB4RLTB4R2MAOB | |
| SCHEMBL7989763 | 0.86 | LTB4R (0.71) | LTB4RLTB4R2MAOB | |
| SCHEMBL7990289 | 0.86 | LTB4R (0.71) | LTB4RLTB4R2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291530-B1 | Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity | NOVARTIS AG (CH) | 2001-09-18 | — | — | US | disclosed |