SCHEMBL7989636

SCHEMBL7989636

CCOC(=O)NC(=N)c1cc[c]c(C)c1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.39
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
GAA P10253 2/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
MAPT P10636 1/20 0.36
ALDH1A1 P00352 2/20 0.35
NPC1 O15118 1/20 0.35
MAPK1 P28482 1/20 0.35
HTT P42858 1/20 0.35
HPGD P15428 1/20 0.35
KLKB1 P03952 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7989160 0.86 KDM4E (0.40) KDM4ECYP1A2CYP2C9CYP2C19GAA
SCHEMBL7988467 0.86 SMN1; SMN2 (0.40) KDM4ECYP1A2CYP2C9CYP2C19GAA
SCHEMBL7988714 0.85 KDM4E (0.40) KDM4ECYP1A2CYP2C9CYP2C19GAA
SCHEMBL7988845 0.83
SCHEMBL7988294 0.82 LMNA (0.37) GAASMN1; SMN2MAPTALDH1A1NPC1
SCHEMBL7988689 0.82 ALDH1A1 (0.39) KDM4ECYP1A2CYP2C9CYP2C19GAA
SCHEMBL7985588 0.81
SCHEMBL7986303 0.80 CYP1A2 (0.43) KDM4ECYP1A2GAASMN1; SMN2MAPT
SCHEMBL7492169 0.77 CA12 (0.54) KDM4ECYP1A2SMN1; SMN2MAPTALDH1A1
SCHEMBL8286194 0.77 GAA (0.54) KDM4ECYP1A2CYP2C9CYP2C19GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6265418-B1 ANTICOAGULANTS UBE INDUSTRIES, LTD. (JP) 2001-07-24 US disclosed
EP-1020467-A1 N-ACYLAMINO ACID AMIDE COMPOUNDS AND INTERMEDIATES FOR PREPARATION THEREOF UBE INDUSTRIES LIMITED (JP) 2000-07-19 EP disclosed