Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.48 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.44 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988152 | 0.91 | SIRT2 (0.61) | SIRT2SIRT1TARBP2MEN1KMT2A | |
| SCHEMBL7991809 | 0.89 | SIRT2 (0.59) | SIRT2SIRT1TARBP2MAPTTP53 | |
| SCHEMBL7987913 | 0.89 | SIRT2 (0.59) | SIRT2SIRT1CHEK2MEN1KMT2A | |
| SCHEMBL7978031 | 0.88 | SIRT2 (0.61) | SIRT2SIRT1CHEK2MEN1KMT2A | |
| SCHEMBL7989667 | 0.88 | SIRT2 (0.61) | SIRT2SIRT1TARBP2MAPTTP53 | |
| SCHEMBL7977935 | 0.86 | CHEK2 (0.53) | SIRT2SIRT1CHEK2MEN1KMT2A | |
| SCHEMBL7989515 | 0.82 | SIRT2 (0.52) | SIRT2SIRT1TARBP2MEN1KMT2A | |
| SCHEMBL7977895 | 0.81 | SIRT2 (0.61) | SIRT2SIRT1TARBP2MAPTGAA | |
| SCHEMBL7977730 | 0.81 | SIRT2 (0.50) | SIRT2SIRT1TARBP2MEN1KMT2A | |
| SCHEMBL7989978 | 0.81 | SIRT2 (0.61) | SIRT2SIRT1CHEK2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288061-B1 | INTERLEUKIN INHIBITORS; ASTHMA, BRONCHODILATOR AGENTS, ANTIALLERGENS | WELFIDE CORPORATION (JP) | 2001-09-11 | — | — | US | disclosed |