Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14879725 | 0.70 | CYP2D6 (0.42) | TSHRHSD17B10POLBMAPTKMT2A | |
| SCHEMBL10932176 | 0.68 | MAPT (0.50) | TSHRHSD17B10POLBMAPTKMT2A | |
| SCHEMBL12480441 | 0.67 | HTT (0.53) | TSHRHSD17B10POLBMAPTHTT | |
| SCHEMBL11307625 | 0.67 | ITGB1 (0.55) | TSHRHSD17B10POLBMAPTKMT2A | |
| SCHEMBL30063005 | 0.67 | MAPT (0.38) | TSHRHSD17B10MAPTKMT2AALOX15 | |
| SCHEMBL4533135 | 0.67 | CYP1A2 (0.42) | TSHRHSD17B10POLBMAPTKMT2A | |
| SCHEMBL4522976 | 0.67 | CYP1A2 (0.42) | TSHRHSD17B10POLBMAPTKMT2A | |
| SCHEMBL9618004 | 0.67 | ALOX15 (0.46) | TSHRHSD17B10MAPTKMT2AALOX15 | |
| SCHEMBL11472678 | 0.65 | CYP1A2 (0.37) | TSHRHSD17B10POLBMAPTKMT2A | |
| SCHEMBL14169017 | 0.64 | MAPT (0.42) | TSHRHSD17B10POLBMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |