SCHEMBL7990249

SCHEMBL7990249

CCCC(Nc1nc(Cl)nc(Cl)n1)C1CC(C)(C)N(OC)C(C)(C)C1

nearest known ligand 0.31

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 1/20 0.31
IDH2 P48735 1/20 0.31
GAA P10253 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
CYP2C9 P11712 1/20 0.30
NPR3 P17342 1/20 0.30
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7458937 0.98 IDH1 (0.33) IDH1IDH2GAATDP1CYP2C9
SCHEMBL9742736 0.91 IDH1 (0.32) IDH1IDH2
SCHEMBL9428391 0.89 KMT2A (0.41) CYP2C9NPR3CYP2C19
SCHEMBL20608531 0.89 GAA (0.33) IDH1IDH2GAATDP1
SCHEMBL8651933 0.89
SCHEMBL692773 0.88 ALDH1A1 (0.31) IDH1IDH2
SCHEMBL698651 0.86 IDH1 (0.33) IDH1IDH2GAATDP1
SCHEMBL9428503 0.85 CYP2D6 (0.30)
SCHEMBL6032700 0.85 TSHR (0.37) GAACYP2C9NPR3CYP2C19
SCHEMBL3260642 0.85 KMT2A (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6265473-B1 STABILIZER; HEAT AND OXIDATION RESISTANCE; PHOTOSTABILITY CIBA SPECIALTY CHEMICALS CORP. 2001-07-24 US disclosed
WO-1998054174-A1 BLOCK OLIGOMERS CONTAINING 1-HYDROCARBYLOXY-2,2,6,6-TETRAMETHYL-4-PIPERIDYL GROUPS AS STABILIZERS FOR ORGANIC MATERIALS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 1998-12-03 WO disclosed