Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 8/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.49 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.48 |
| ▸ | MLNR | O43193 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12126042 | 0.90 | TLR4 (0.50) | TLR4ADRB2DNM1ADRB3ADRB1 | |
| SCHEMBL5375723 | 0.90 | ADRB2 (0.62) | TLR4ADRB2DNM1ADRB3ADRB1 | |
| SCHEMBL4555826 | 0.81 | ADRB2 (0.68) | TLR4ADRB2DNM1ADRB3ADRB1 | |
| SCHEMBL8277013 | 0.81 | ADRB2 (0.68) | TLR4ADRB2DNM1ADRB3ADRB1 | |
| SCHEMBL10365830 | 0.81 | POLB (0.60) | DRD2MAPTABCB1GAADRD4 | |
| SCHEMBL2993363 | 0.80 | TLR4 (0.69) | TLR4ADRB2DNM1ADRB3ADRB1 | |
| SCHEMBL10772352 | 0.80 | ALDH1A1 (0.47) | DRD2MAPTKDM4EABCB1GAA | |
| SCHEMBL10123780 | 0.79 | ADRB2 (0.65) | TLR4ADRB2DNM1ADRB3ADRB1 | |
| SCHEMBL14582544 | 0.77 | ADRB2 (0.63) | TLR4ADRB2DNM1ADRB3ADRB1 | |
| SCHEMBL8291496 | 0.76 | ADRB2 (0.79) | TLR4ADRB2DNM1ADRB3ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115902-A1 | PROCESS FOR THE PREPARATION OF CARVEDILOL VIA SILYL PROTECTION OF SUBSTITUTED AMINE | CADILA PHARMACEUTICALS LTD. (IN) | 2009-09-24 | — | — | WO | disclosed |