Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990776 | 1.00 | CYP11B1 (0.55) | CYP11B1CYP11B2TBXAS1CYP1A2USP2 | |
| SCHEMBL7995116 | 0.84 | CYP11B1 (0.52) | CYP11B1CYP11B2TBXAS1CYP1A2USP2 | |
| SCHEMBL7995117 | 0.84 | CYP11B1 (0.52) | CYP11B1CYP11B2TBXAS1CYP1A2USP2 | |
| SCHEMBL7981226 | 0.79 | CYP11B1 (0.58) | CYP11B1CYP11B2TBXAS1 | |
| SCHEMBL8140959 | 0.78 | CYP11B1 (0.67) | CYP11B1CYP11B2CYP3A4ALDH1A1 | |
| SCHEMBL1758083 | 0.76 | CYP11B1 (0.68) | CYP11B1CYP11B2LMNAALDH1A1 | |
| SCHEMBL7700254 | 0.75 | CYP11B1 (0.67) | CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL7986619 | 0.75 | CYP11B1 (0.67) | CYP11B1CYP11B2 | |
| SCHEMBL7696780 | 0.75 | CYP11B1 (0.67) | CYP11B1CYP11B2LMNAKMT2AALDH1A1 | |
| SCHEMBL765399 | 0.75 | CYP11B1 (0.67) | CYP11B1CYP11B2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001009124-A1 | 8-CARBONYL CHROMAN DERIVATIVES, PREPARATION AND THERAPIC USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2001-02-08 | — | — | WO | disclosed |
| WO-2001009112-A1 | NOVEL 8-CARBONYL CHROMAN DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2001-02-08 | — | — | WO | disclosed |