SCHEMBL7990781

SCHEMBL7990781

Cn1cc(C2=C(c3c[nH]c4cc(N5CCCC5)ccc34)C(=O)NC2=O)c2ccc(Cl)cc21

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 1/20 0.56
CDK4 P11802 4/20 0.54
CCND1 P24385 4/20 0.54
CDK2 P24941 4/20 0.54
CCNE2 O96020 3/20 0.54
CCNE1 P24864 3/20 0.54
PRKACA P17612 2/20 0.54
PRKACG P22612 2/20 0.54
PRKACB P22694 2/20 0.54
GSK3B P49841 4/20 0.51
GSK3A P49840 2/20 0.51
MEN1 O00255 1/20 0.51
RGS12 O14924 1/20 0.51
GMNN O75496 1/20 0.51
USP2 O75604 1/20 0.51
CCNB2 O95067 1/20 0.51
LMNA P02545 1/20 0.51
TP53 P04637 1/20 0.51
CYP1A2 P05177 1/20 0.51
CDK1 P06493 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7524580 0.90 GSK3B (0.58) CDK4CCND1CDK2CCNE2CCNE1
SCHEMBL7594754 0.89 CDK4 (0.67) IDH1CDK4CCND1CDK2CCNE2
SCHEMBL7597574 0.86 CCNE2 (0.69) CDK4CCND1CDK2CCNE2CCNE1
SCHEMBL7599053 0.85 CCNE2 (0.51) IDH1CDK4CCND1CDK2CCNE2
SCHEMBL7976147 0.83 GSK3B (0.56) CDK4CCND1CDK2CCNE2CCNE1
SCHEMBL7598834 0.81 CDK4 (0.65) IDH1CDK4CCND1CDK2CCNE2
SCHEMBL7990993 0.81 CDK2 (0.67) CDK4CCND1CDK2CCNE2CCNE1
SCHEMBL7986966 0.80 PRKACA (0.66) CDK4CCND1CDK2CCNE2CCNE1
SCHEMBL7976776 0.78 CDK4 (0.67) CDK4CCND1CDK2CCNE2CCNE1
SCHEMBL7987101 0.77 CDK4 (0.66) CDK4CCND1CDK2CCNE2CCNE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6281356-B1 ANTICANRCER AGENTS HOFFMANN-LA ROCHE INC. 2001-08-28 US claimed
US-6281356-B1 ANTICANRCER AGENTS HOFFMANN-LA ROCHE INC. 2001-08-28 US disclosed