Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.67 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.67 |
| ▸ | CDK4 | P11802 | 4/20 | 0.67 |
| ▸ | CCND1 | P24385 | 4/20 | 0.67 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.67 |
| ▸ | PRKACA | P17612 | 3/20 | 0.67 |
| ▸ | PRKACG | P22612 | 3/20 | 0.67 |
| ▸ | PRKACB | P22694 | 3/20 | 0.67 |
| ▸ | GSK3B | P49841 | 9/20 | 0.65 |
| ▸ | JAK1 | P23458 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.59 |
| ▸ | PRKCB | P05771 | 7/20 | 0.53 |
| ▸ | PRKCA | P17252 | 7/20 | 0.53 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.53 |
| ▸ | PRKCG | P05129 | 7/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.52 |
| ▸ | PRKCH | P24723 | 2/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986966 | 0.93 | PRKACA (0.66) | CDK2CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7530443 | 0.90 | GSK3B (0.72) | CDK2CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7598834 | 0.89 | CDK4 (0.65) | CDK2CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7597574 | 0.84 | CCNE2 (0.69) | CDK2CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL6586180 | 0.83 | GSK3B (0.69) | CDK2CCNE2CDK4CCND1CCNE1 | |
| Hydrochloric Acid SCHEMBL6582692 | 0.82 | GSK3B (0.67) | CDK2CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7822250 | 0.81 | CDK4 (1.00) | CDK2CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7594754 | 0.81 | CDK4 (0.67) | CDK2CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7990781 | 0.81 | IDH1 (0.56) | CDK2CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL16934843 | 0.81 | CCNE2 (1.00) | CDK2CCNE2CDK4CCND1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | claimed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |