Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.52 |
| ▸ | PRKCA | P17252 | 4/20 | 0.42 |
| ▸ | PRKCB | P05771 | 3/20 | 0.42 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.39 |
| ▸ | FLT1 | P17948 | 3/20 | 0.36 |
| ▸ | FLT4 | P35916 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | PRKCH | P24723 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550081 | 0.92 | KDR (0.56) | KDRPRKCAPRKCBPRKCEGRIN2B | |
| SCHEMBL7976631 | 0.91 | KDR (0.53) | KDRPRKCAPRKCBPRKCEFLT1 | |
| SCHEMBL7986680 | 0.89 | KDR (0.49) | KDRFLT1FLT4TLR8PRKACA | |
| SCHEMBL7550695 | 0.87 | KDR (0.69) | KDRPRKCAPRKCBPRKCEFLT1 | |
| SCHEMBL7557466 | 0.85 | KDR (0.73) | KDRPRKCAPRKCBPRKCEFLT1 | |
| SCHEMBL7976734 | 0.85 | KDR (0.50) | KDRPRKCAPRKCBPRKCEFLT1 | |
| SCHEMBL7987952 | 0.85 | KDR (0.58) | KDRPRKCAPRKCBPRKCEGRIN2B | |
| SCHEMBL7976106 | 0.85 | KDR (0.58) | KDRPRKCAPRKCBPRKCEGRIN2B | |
| SCHEMBL7502702 | 0.85 | KDR (0.46) | KDRPRKCAPRKCBPRKCEGRIN2B | |
| SCHEMBL7976532 | 0.84 | KDR (0.51) | KDRPRKCAPRKCBPRKCEGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |