Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.58 |
| ▸ | PRKCA | P17252 | 3/20 | 0.44 |
| ▸ | PRKCB | P05771 | 2/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 3/20 | 0.41 |
| ▸ | FLT4 | P35916 | 3/20 | 0.41 |
| ▸ | MAT2A | P31153 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | PRKCH | P24723 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | PRKACB | P22694 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 2/20 | 0.37 |
| ▸ | FNTB | P49356 | 2/20 | 0.37 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7554248 | 0.93 | KDR (0.62) | KDRPRKCAPRKCBPRKCEFLT1 | |
| SCHEMBL7550695 | 0.92 | KDR (0.69) | KDRPRKCAPRKCBPRKCEFLT1 | |
| SCHEMBL7976106 | 0.92 | KDR (0.58) | KDRPRKCAPRKCBPRKCEFLT1 | |
| SCHEMBL7993919 | 0.91 | KDR (0.58) | KDRPRKCAPRKCBPRKCEFLT1 | |
| SCHEMBL7993991 | 0.91 | KDR (0.53) | KDRPRKCAPRKCBPRKCEHTR6 | |
| SCHEMBL7546697 | 0.91 | KDR (0.53) | KDRPRKCAPRKCBPRKCEFLT1 | |
| SCHEMBL7507970 | 0.90 | KDR (0.52) | KDRPRKCAPRKCBPRKCEFLT1 | |
| SCHEMBL7990591 | 0.85 | KDR (0.53) | KDRPRKCAPRKCBPRKCEFLT1 | |
| SCHEMBL7990794 | 0.85 | KDR (0.52) | KDRPRKCAPRKCBPRKCEFLT1 | |
| SCHEMBL7550957 | 0.84 | KDR (0.62) | KDRPRKCAPRKCBPRKCEFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |