Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 17/20 | 0.71 |
| ▸ | LTB4R2 | Q9NPC1 | 17/20 | 0.71 |
| ▸ | RORC | P51449 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990834 | 1.00 | LTB4R (0.71) | LTB4RLTB4R2RORCLRRK2 | |
| SCHEMBL7990835 | 1.00 | LTB4R (0.71) | LTB4RLTB4R2RORCLRRK2 | |
| SCHEMBL7986905 | 0.90 | LTB4R (0.74) | LTB4RLTB4R2RORCLRRK2 | |
| SCHEMBL7986904 | 0.90 | LTB4R (0.74) | LTB4RLTB4R2RORCLRRK2 | |
| SCHEMBL7986902 | 0.90 | LTB4R (0.74) | LTB4RLTB4R2RORCLRRK2 | |
| SCHEMBL7990142 | 0.83 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL7986581 | 0.83 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL7990140 | 0.83 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL383026 | 0.80 | LTB4R (0.60) | LTB4RLTB4R2RORC | |
| SCHEMBL8420271 | 0.77 | LTB4R (0.52) | LTB4RLTB4R2RORCLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291530-B1 | Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity | NOVARTIS AG (CH) | 2001-09-18 | — | — | US | disclosed |