Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 13/20 | 0.52 |
| ▸ | LTB4R2 | Q9NPC1 | 13/20 | 0.52 |
| ▸ | RORC | P51449 | 3/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7168158 | 0.83 | LTB4R (0.54) | LTB4RLTB4R2RORCLRRK2KDM4E | |
| SCHEMBL7990834 | 0.77 | LTB4R (0.71) | LTB4RLTB4R2RORCLRRK2 | |
| SCHEMBL7990836 | 0.77 | LTB4R (0.71) | LTB4RLTB4R2RORCLRRK2 | |
| SCHEMBL7990835 | 0.77 | LTB4R (0.71) | LTB4RLTB4R2RORCLRRK2 | |
| SCHEMBL10591294 | 0.76 | LTB4R (0.54) | LTB4RLTB4R2RORCLRRK2KDM4E | |
| SCHEMBL10698079 | 0.75 | LTB4R (0.53) | LTB4RLTB4R2RORCLRRK2 | |
| SCHEMBL312341 | 0.75 | LTB4R (0.53) | LTB4RLTB4R2RORCLRRK2KDM4E | |
| SCHEMBL8420264 | 0.75 | KDM4E (0.49) | KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL7986905 | 0.74 | LTB4R (0.74) | LTB4RLTB4R2RORCLRRK2 | |
| SCHEMBL7986902 | 0.74 | LTB4R (0.74) | LTB4RLTB4R2RORCLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |