Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.32 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988235 | 0.93 | HRH3 (0.40) | HRH3GRK6CTSSCTSKKMT2A | |
| SCHEMBL4378007 | 0.81 | KMT2A (0.48) | HRH3KMT2AMEN1ALDH1A1 | |
| SCHEMBL4386828 | 0.77 | HRH3 (0.46) | HRH3GRK6KMT2AMEN1POLB | |
| SCHEMBL7994747 | 0.75 | KDM4E (0.45) | HRH3GRK6CTSKKMT2AMEN1 | |
| Oxalic Acid SCHEMBL7977323 | 0.75 | HRH3 (0.43) | HRH3GRK6KMT2AMEN1POLB | |
| SCHEMBL7994706 | 0.70 | CHEK1 (0.36) | HRH3POLBLMNARAB9AMAPT | |
| SCHEMBL4379711 | 0.70 | HRH3 (0.43) | HRH3GRK6KMT2AMEN1LMNA | |
| SCHEMBL17052735 | 0.69 | HDAC1 (0.45) | KMT2AMEN1LMNAHPGDRAB9A | |
| SCHEMBL7991427 | 0.69 | HRH3 (0.37) | HRH3POLBLMNAMAPT | |
| SCHEMBL11725367 | 0.68 | HDAC1 (0.52) | KMT2AMEN1LMNAHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | claimed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |