Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GRK6 | P43250 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4386828 | 0.97 | HRH3 (0.46) | HRH3APEX1ALDH1A1POLBKMT2A | |
| Oxalic Acid SCHEMBL7988233 | 0.93 | HRH3 (0.41) | HRH3APEX1ALDH1A1POLBKMT2A | |
| SCHEMBL4379711 | 0.90 | HRH3 (0.43) | HRH3APEX1ALDH1A1KMT2ASMN1; SMN2 | |
| Oxalic Acid SCHEMBL8934783 | 0.82 | MAPT (0.34) | ALDH1A1KDM4EPOLBKMT2ASMN1; SMN2 | |
| Oxalic Acid SCHEMBL4378004 | 0.81 | MAOB (0.47) | HRH3ALDH1A1KMT2ARAB9AMAOB | |
| SCHEMBL4379687 | 0.78 | KMT2A (0.50) | HRH3ALDH1A1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL4543312 | 0.77 | KMT2A (0.49) | HRH3ALDH1A1KMT2AMAOBMEN1 | |
| SCHEMBL7991004 | 0.75 | HRH3 (0.42) | HRH3APEX1ALDH1A1POLBKMT2A | |
| Oxalic Acid SCHEMBL7994745 | 0.74 | GAA (0.46) | HRH3ALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL4379745 | 0.74 | HPGD (0.43) | ALDH1A1KMT2ASMN1; SMN2RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | claimed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | claimed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |