Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7526044 | 0.79 | TSHR (0.56) | TSHRTP53TDP1PPARDNPSR1 | |
| SCHEMBL5015252 | 0.77 | TSHR (0.53) | TSHRTP53TDP1PPARDNPSR1 | |
| SCHEMBL6631037 | 0.74 | TSHR (0.50) | TSHRTP53TDP1PPARDNPSR1 | |
| SCHEMBL1396448 | 0.74 | TSHR (0.50) | TSHRTP53TDP1PPARDNPSR1 | |
| SCHEMBL11336903 | 0.74 | TSHR (0.43) | TSHRTP53TDP1PPARDNPSR1 | |
| SCHEMBL27799341 | 0.74 | PPARD (0.44) | TSHRTP53TDP1PPARDNPSR1 | |
| SCHEMBL27339414 | 0.74 | TSHR (0.39) | TSHRTP53TDP1PPARDNPSR1 | |
| SCHEMBL4797316 | 0.72 | TSHR (0.48) | TSHRTP53TDP1PPARDNPSR1 | |
| SCHEMBL19837991 | 0.72 | TSHR (0.48) | TSHRTP53TDP1PPARDNPSR1 | |
| SCHEMBL5357461 | 0.72 | TSHR (0.48) | TSHRTP53TDP1PPARDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6320040-B1 | PREPARING NOVEL NUCLEOSIDE OLIGOMERS BEARING PENDANT CONJUGATE GROUPS FOR INCORPORATION INTO NUCLEIC ACIDS | ISIS PHARMACEUTICALS, INC. | 2001-11-20 | — | — | US | disclosed |
| US-5998603-A | TETRAHYDROFURANYL COMPOUNDS ARE PROVIDED THAT ARE FUNCTIONALIZED TO INCLUDE PENDANT CONJUGATE GROUPS | ISIS PHARMACEUTICALS, INC. (US) | 1999-12-07 | — | — | US | disclosed |
| WO-1996010030-A1 | OLIGOMERS HAVING HETEROATOM-LINKED CONJUGATE GROUPS | ISIS PHARMACEUTICALS, INC. (US) | 1996-04-04 | — | — | WO | disclosed |