Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 13/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL798708 | 0.87 | PIK3CG (0.48) | PIK3CGPIK3CDKDM4EJAK2 | |
| SCHEMBL799272 | 0.85 | PIK3CG (0.51) | PIK3CGROCK2KDM4E | |
| SCHEMBL799155 | 0.83 | ROCK2 (0.39) | PIK3CGROCK2PIK3CDKDM4E | |
| SCHEMBL798720 | 0.81 | GCK (0.50) | PIK3CGROCK2PIK3CDKDM4EJAK2 | |
| SCHEMBL798724 | 0.80 | PIK3CG (0.49) | PIK3CGROCK2KDM4E | |
| SCHEMBL805069 | 0.80 | PIK3CG (0.40) | PIK3CGROCK2PIK3CDKDM4EJAK2 | |
| SCHEMBL798956 | 0.79 | PIK3CG (0.40) | PIK3CGPIK3CDKDM4EJAK2 | |
| SCHEMBL799338 | 0.79 | PIK3CG (0.41) | PIK3CGROCK2PIK3CDKDM4EJAK2 | |
| SCHEMBL799301 | 0.78 | PIK3CG (0.46) | PIK3CGROCK2PIK3CDJAK2 | |
| SCHEMBL799096 | 0.75 | ROCK2 (0.48) | PIK3CGROCK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-03-22 | — | — | US | disclosed |
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | MTOR, STAT3, SLC14A1 | PIK3CG 16/4885ROCK2 2264/4885PIK3CD 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.