Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 9/20 | 0.64 |
| ▸ | HTR1A | P08908 | 5/20 | 0.55 |
| ▸ | HTR2A | P28223 | 5/20 | 0.55 |
| ▸ | DRD2 | P14416 | 4/20 | 0.55 |
| ▸ | DRD5 | P21918 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 3/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8671953 | 0.80 | HTR7 (0.51) | HTR7HTR1AHTR2ADRD2DRD5 | |
| SCHEMBL7989958 | 0.80 | HTR7 (0.64) | HTR7HTR1AHTR2ADRD2DRD5 | |
| SCHEMBL7991560 | 0.77 | HTR7 (0.66) | HTR7HTR1AHTR2ADRD2DRD5 | |
| SCHEMBL11465528 | 0.77 | SIGMAR1 (0.76) | HTR7HTR1AHTR2ADRD2ADRA1A | |
| SCHEMBL7993442 | 0.76 | HTR7 (0.64) | HTR7DRD2DRD5DRD3SIGMAR1 | |
| SCHEMBL13875122 | 0.76 | SIGMAR1 (0.71) | HTR7HTR1ADRD2ADRA1ADRD3 | |
| Hydrochloric Acid SCHEMBL7996662 | 0.75 | HTR7 (0.63) | HTR7DRD2DRD5DRD3SIGMAR1 | |
| SCHEMBL7993172 | 0.75 | HTR7 (0.68) | HTR7HTR1ADRD2DRD5DRD3 | |
| SCHEMBL13875120 | 0.75 | SIGMAR1 (0.69) | HTR7HTR1ADRD2DRD3SIGMAR1 | |
| SCHEMBL11405931 | 0.75 | SIGMAR1 (0.69) | HTR7HTR1AHTR2ADRD2DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284775-B1 | PSYCHOLOGICAL DISORDERS | AVENTIS PHARMACEUTICALS INC. | 2001-09-04 | — | — | US | disclosed |
| US-5801186-A | ANTIPSYCHOTIC AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1998-09-01 | — | — | US | disclosed |
| US-5371087-A | Antipsychotic, analgesics, anticonvulsant and anxiolytic agent | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-12-06 | — | — | US | disclosed |
| US-5229388-A | 3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-20 | — | — | US | disclosed |