Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 11/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CHUK | O15111 | 3/20 | 0.35 |
| ▸ | EPHA3 | P29320 | 3/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30468111 | 0.84 | SMN1; SMN2 (0.33) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL11185663 | 0.74 | LMNA (0.40) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL17629367 | 0.72 | SMN1; SMN2 (0.39) | IKBKBSMN1; SMN2LMNAALDH1A1CHUK | |
| SCHEMBL28218356 | 0.68 | SMN1; SMN2 (0.35) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1845394 | 0.67 | LMNA (0.35) | SMN1; SMN2LMNAALDH1A1KMT2ACYP3A4 | |
| SCHEMBL1845392 | 0.67 | LMNA (0.35) | SMN1; SMN2LMNAALDH1A1KMT2ACYP3A4 | |
| SCHEMBL6272138 | 0.67 | KMT2A (0.56) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL10639290 | 0.66 | LMNA (0.40) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL13464120 | 0.66 | HTT (0.41) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL13545968 | 0.66 | ALDH1A1 (0.40) | LMNAALDH1A1PDGFRAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303602-B1 | USEFUL AS ANALGESIC, ANESTHETIC, ANTI-INFLAMMATORY OR NEUROPROTECTIVE AGENT, OR FOR THERAPY OF ARTHRITIS, STROKE OF FUNCTIONAL BOWEL DISEASE | PFIZER INC. | 2001-10-16 | — | — | US | disclosed |
| EP-0934264-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998012177-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (JP) | 1998-03-26 | — | — | WO | disclosed |