Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 0.88 |
| ▸ | HTR2B | P41595 | 7/20 | 0.88 |
| ▸ | DRD2 | P14416 | 4/20 | 0.88 |
| ▸ | HTR2C | P28335 | 4/20 | 0.88 |
| ▸ | HTR1A | P08908 | 2/20 | 0.66 |
| ▸ | HTR1D | P28221 | 1/20 | 0.66 |
| ▸ | HTR1B | P28222 | 1/20 | 0.66 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4278516 | 0.99 | HTR6 (0.87) | HTR6HTR2BDRD2HTR2CHTR1A | |
| SCHEMBL7991196 | 0.94 | HTR6 (1.00) | HTR6HTR2BDRD2HTR2CHTR1A | |
| Hydrochloric Acid SCHEMBL4279101 | 0.93 | HTR6 (0.98) | HTR6HTR2BDRD2HTR2CHTR1A | |
| SCHEMBL3948495 | 0.90 | HTR6 (0.88) | HTR6HTR2BDRD2HTR2CHTR1A | |
| SCHEMBL7982759 | 0.85 | HTR6 (1.00) | HTR6HTR2BDRD2HTR2CHTR1A | |
| Hydrochloric Acid SCHEMBL4280871 | 0.84 | HTR6 (0.98) | HTR6HTR2BDRD2HTR2CHTR1A | |
| SCHEMBL7996043 | 0.83 | HTR6 (1.00) | HTR6HTR2BDRD2HTR2CHTR1A | |
| SCHEMBL7994408 | 0.82 | HTR6 (1.00) | HTR6HTR2BDRD2HTR2CHTR1A | |
| Hydrochloric Acid SCHEMBL4287165 | 0.82 | HTR6 (0.98) | HTR6HTR2BDRD2HTR2CHTR1A | |
| Hydrochloric Acid SCHEMBL4432258 | 0.82 | HTR6 (0.98) | HTR6HTR2BDRD2HTR2CHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318470-A1 | 1-SUBSTITUTED-3-(NAPHTHALEN-1-YLSULFONYL)-5-(PIPERAZIN-1-YL)-1H-INDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2009-12-24 | — | — | US | disclosed |
| US-20090318470-A1 | 1-SUBSTITUTED-3-(NAPHTHALEN-1-YLSULFONYL)-5-(PIPERAZIN-1-YL)-1H-INDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2009-12-24 | — | — | US | disclosed |
| WO-2009155399-A1 | 1-SUBSTITUTED-3-(NAPHTHALEN-1-YLSULFONYL)-5-(PIPERAZIN-1-YL)-1H-INDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318470-A1 | 1-SUBSTITUTED-3-(NAPHTHALEN-1-YLSULFONYL)-5-(PIPERAZIN-1-YL)-1H-INDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | HTR6, TPH1, HTR2C | HTR6 1/4885HTR2B 17/4885DRD2 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.