Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | KLK7 | P49862 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2648207 | 0.81 | MEN1 (0.51) | TDP1ALDH1A1USP2ALOX15L3MBTL1 | |
| SCHEMBL7886952 | 0.81 | ALDH1A1 (0.49) | TDP1ALDH1A1USP2ALOX15L3MBTL1 | |
| SCHEMBL6477414 | 0.80 | ALDH1A1 (0.44) | TDP1ALDH1A1USP2ALOX15L3MBTL1 | |
| SCHEMBL9744436 | 0.80 | MEN1 (0.54) | TDP1ALDH1A1USP2ALOX15L3MBTL1 | |
| SCHEMBL18311726 | 0.80 | MEN1 (0.54) | TDP1ALDH1A1USP2ALOX15L3MBTL1 | |
| SCHEMBL1172293 | 0.80 | MEN1 (0.54) | TDP1ALDH1A1USP2ALOX15L3MBTL1 | |
| SCHEMBL31323929 | 0.80 | MEN1 (0.54) | TDP1ALDH1A1USP2ALOX15L3MBTL1 | |
| SCHEMBL6050437 | 0.78 | NAAA (0.36) | — | |
| SCHEMBL18623243 | 0.77 | ALDH1A1 (0.50) | TDP1ALDH1A1USP2ALOX15L3MBTL1 | |
| SCHEMBL555314 | 0.75 | SMYD3 (0.38) | ALDH1A1L3MBTL1KMT2AMEN1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232324-B1 | AS HYPERTENSIVE AGENTS FOR DIALYSIS INDUCED HYPOTENSION; ADMINISTERING COMPOUNDS SUCH AS 1-(3-(2-PHENYLPYRAZOLO(1,5-A) PYRIDIN-3-YL)ACRYLOYL)-2-(CARBOXY METHYL)PIPERIDINE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-05-15 | — | — | US | disclosed |