Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 11/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1114289 | 0.88 | PIK3CA (0.63) | PIK3CAFLT3MTORPIK3CGPIK3CD | |
| SCHEMBL13673773 | 0.88 | FLT3 (0.47) | PIK3CAFLT3YTHDC1MTORPIK3CG | |
| SCHEMBL9605491 | 0.79 | MTOR (0.45) | PIK3CAFLT3MTORPIK3CGPIK3CD | |
| SCHEMBL336325 | 0.79 | MTOR (0.45) | PIK3CAFLT3MTORPIK3CGPIK3CD | |
| SCHEMBL336324 | 0.79 | PIK3CA (0.43) | PIK3CAFLT3MTORPIK3CGPIK3CD | |
| SCHEMBL336678 | 0.78 | PIK3CA (0.53) | PIK3CAMTORPIK3CGPIK3CDPIK3R1 | |
| SCHEMBL1113912 | 0.78 | YTHDC1 (0.62) | PIK3CAFLT3YTHDC1MTORPIK3CG | |
| SCHEMBL31373063 | 0.78 | YTHDC1 (0.62) | PIK3CAFLT3YTHDC1MTORPIK3CG | |
| SCHEMBL20171893 | 0.78 | FLT3 (0.56) | PIK3CAFLT3YTHDC1MTORPIK3CG | |
| SCHEMBL337155 | 0.75 | PIK3CA (0.49) | PIK3CAMTORPIK3CGPIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309546-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-11-13 | — | — | US | disclosed |
| US-8309546-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-11-13 | — | — | US | disclosed |
| US-20120071476-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
| US-20120071476-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
| US-8097622-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-01-17 | — | — | US | disclosed |
| US-8097622-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-01-17 | — | — | US | disclosed |
| US-20100130492-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-27 | — | — | US | disclosed |
| US-20100130492-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130492-A1 | MORPHOLINOPURINE DERIVATIVES | MTOR, RICTOR, PIK3R1 | PIK3CA 22/4885FLT3 2698/4885YTHDC1 581/4885 |
| US-20120071476-A1 | MORPHOLINOPURINE DERIVATIVES | MTOR, RICTOR, PIK3R1 | PIK3CA 22/4885FLT3 2698/4885YTHDC1 581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.