Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 15/20 | 0.50 |
| ▸ | CA1 | P00915 | 14/20 | 0.50 |
| ▸ | CA12 | O43570 | 10/20 | 0.50 |
| ▸ | CA7 | P43166 | 7/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.50 |
| ▸ | CA9 | Q16790 | 11/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 4/20 | 0.40 |
| ▸ | CA6 | P23280 | 4/20 | 0.40 |
| ▸ | CA5A | P35218 | 4/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30232448 | 0.85 | CA2 (0.50) | CA2CA1CA12CA7CA14 | |
| SCHEMBL4239331 | 0.85 | CA2 (0.50) | CA2CA1CA12CA7CA14 | |
| SCHEMBL27675520 | 0.84 | CA2 (0.49) | CA2CA1CA12CA7CA14 | |
| SCHEMBL27052187 | 0.81 | CA1 (0.46) | CA2CA1CA12CA7CA14 | |
| SCHEMBL30311540 | 0.81 | CA1 (0.46) | CA2CA1CA12CA7CA14 | |
| SCHEMBL17771331 | 0.78 | CA12 (0.41) | CA2CA1CA12CA7CA14 | |
| Benzenesulfonamide SCHEMBL27317322 | 0.75 | CA2 (0.55) | CA2CA1CA12CA7CA14 | |
| SCHEMBL30232425 | 0.74 | CA1 (0.46) | CA2CA1CA12CA7CA14 | |
| SCHEMBL8353563 | 0.71 | CA2 (0.51) | CA2CA1CA12CA7CA14 | |
| SCHEMBL9079118 | 0.71 | CA1 (0.44) | CA2CA1CA12CA7CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281240-B1 | CYSTIC FIBROSIS | ELI LILLY AND COMPANY | 2001-08-28 | — | — | US | disclosed |
| WO-1998044799-A1 | DIARYLSULFONYLUREAS FOR USE IN TREATING SECRETORY DIARRHEA | ELI LILLY AND COMPANY (US) | 1998-10-15 | — | — | WO | disclosed |
| EP-0606723-A1 | Imidazolidin-2-one derivatives and their use as antitumor agents | ELI LILLY AND COMPANY (US) | 1994-07-20 | — | — | EP | disclosed |
| US-5270329-A | 1-arylsulfonyl-imidazolidin-2-one derivatives | ELI LILLY AND COMPANY (US) | 1993-12-14 | — | — | US | disclosed |
| US-5262440-A | Treatment of neoplasms | ELI LILLY AND COMPANY (US) | 1993-11-16 | — | — | US | disclosed |
| EP-0546763-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-06-16 | — | — | EP | disclosed |