Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 14/20 | 0.46 |
| ▸ | CA2 | P00918 | 14/20 | 0.46 |
| ▸ | CA12 | O43570 | 9/20 | 0.46 |
| ▸ | CA7 | P43166 | 7/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.46 |
| ▸ | CA9 | Q16790 | 10/20 | 0.41 |
| ▸ | PNMT | P11086 | 3/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 4/20 | 0.37 |
| ▸ | CA6 | P23280 | 4/20 | 0.37 |
| ▸ | CA5A | P35218 | 4/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30232426 | 0.87 | CA1 (0.46) | CA1CA2CA12CA7CA14 | |
| SCHEMBL12988642 | 0.75 | CA2 (0.45) | CA1CA2CA12CA7CA14 | |
| SCHEMBL7993133 | 0.74 | CA2 (0.50) | CA1CA2CA12CA7CA14 | |
| SCHEMBL30938026 | 0.73 | LMNA (0.39) | CA1CA2CA12CA9LMNA | |
| SCHEMBL6121352 | 0.69 | CA2 (0.63) | CA1CA2CA12CA7CA14 | |
| SCHEMBL9079118 | 0.68 | CA1 (0.44) | CA1CA2CA12CA7CA14 | |
| SCHEMBL29902411 | 0.65 | MEN1 (0.63) | CA1CA2CA12CA7CA14 | |
| SCHEMBL6987442 | 0.64 | CA1 (0.61) | CA1CA2CA12CA7CA14 | |
| SCHEMBL30688580 | 0.64 | CA1 (0.61) | CA1CA2CA12CA7CA14 | |
| SCHEMBL30688582 | 0.64 | CA1 (0.61) | CA1CA2CA12CA7CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230104936-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230104936-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | CA1 1974/4885CA2 294/4885CA12 3100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.