Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29788858 | 0.94 | KIF11 (0.41) | CSNK1EKIF11CNR2KDM4ELMNA | |
| Water SCHEMBL11570733 | 0.84 | CSNK1E (0.44) | CSNK1EKIF11OPRM1CNR2GRIK1 | |
| SCHEMBL8170752 | 0.82 | SIGMAR1 (0.39) | CSNK1EKIF11CNR2 | |
| Hydrochloric Acid SCHEMBL11616125 | 0.82 | CSNK1E (0.43) | CSNK1EKIF11OPRM1CNR2TAAR1 | |
| Hexapradol SCHEMBL1816624 | 0.82 | KDM4E (0.53) | CSNK1EKIF11OPRM1CNR2CES2 | |
| Water SCHEMBL11433620 | 0.82 | CSNK1E (0.43) | CSNK1EKIF11OPRM1CNR2GRIK1 | |
| Water SCHEMBL11260622 | 0.82 | CSNK1E (0.46) | CSNK1EKIF11OPRM1GRIK1GRIK2 | |
| SCHEMBL483815 | 0.82 | CSNK1E (0.46) | CSNK1EKIF11OPRM1GRIK1GRIK2 | |
| Water SCHEMBL11573895 | 0.82 | CSNK1E (0.46) | CSNK1EKIF11OPRM1GRIK1GRIK2 | |
| SCHEMBL10726204 | 0.82 | CSNK1E (0.46) | CSNK1EKIF11OPRM1GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0716604-A4 | THIOL-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES | ISIS PHARMACEUTICALS INC (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-0716604-A1 | THIOL-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 1996-06-19 | — | — | EP | disclosed |
| WO-1995006474-A1 | THIOL-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 1995-03-09 | — | — | WO | disclosed |