Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene Glycol SCHEMBL7527989 | 0.98 | KDM4E (0.59) | KDM4ETSHRTP53NR1H4GRIN2D | |
| Terephthalic Acid SCHEMBL2846917 | 0.91 | TSHR (0.67) | KDM4ETSHRTP53SRD5A2PTPN1 | |
| Beta-Naphtoic Acid SCHEMBL27506155 | 0.90 | NR1H4 (0.61) | KDM4ETP53NR1H4PTPN1ALDH1A1 | |
| 1,4-Butanediol SCHEMBL9127352 | 0.89 | KDM4E (0.55) | KDM4ETSHRTP53NR1H4GRIN2D | |
| 1,3-Propanediol SCHEMBL3356738 | 0.89 | KDM4E (0.55) | KDM4ETSHRTP53NR1H4GRIN2D | |
| SCHEMBL29359975 | 0.88 | KDM4E (0.68) | KDM4ETSHRTP53GRIN2DGRIN2A | |
| SCHEMBL18758 | 0.88 | KDM4E (0.68) | KDM4ETSHRTP53GRIN2DGRIN2A | |
| SCHEMBL29594563 | 0.88 | KDM4E (0.68) | KDM4ETSHRTP53GRIN2DGRIN2A | |
| SCHEMBL6916181 | 0.88 | KDM4E (0.68) | KDM4ETSHRTP53GRIN2DGRIN2A | |
| Alcohol SCHEMBL28996062 | 0.86 | KDM4E (0.62) | KDM4ETSHRTP53GRIN2DGRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6140034-A | LIGHT SENSITIVE ELEMENTS AND PHOTOGRAPHY WITH SUPPORTS AND LAYERS | FUJI PHOTO FILM CO., LTD. (JP) | 2000-10-31 | — | — | US | disclosed |
| US-6030755-A | HEAT DEVELOPMENT | FUJI PHOTO FILM CO., LTD. (JP) | 2000-02-29 | — | — | US | disclosed |
| US-6022673-A | MIXTURE OF SILVER HALIDE PARTICLES, DEVELOPER, COUPLER AND BINDER | FUJI PHOTO FILM CO., LTD. (JP) | 2000-02-08 | — | — | US | disclosed |
| US-6001543-A | COLOR PHOTOGRAPHY | FUJI PHOTO FILM CO., LTD. (JP) | 1999-12-14 | — | — | US | disclosed |