Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | PNP | P00491 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11298020 | 0.83 | EGFR (0.47) | SMN1; SMN2ALDH1A1ARMEN1GAA | |
| SCHEMBL2864047 | 0.81 | KDM4E (0.51) | LMNASMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL27967775 | 0.81 | LMNA (0.48) | LMNASMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL2870405 | 0.81 | LMNA (0.51) | LMNASMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL2869028 | 0.79 | KDM4E (0.46) | LMNASMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL2867291 | 0.78 | KDM4E (0.48) | LMNASMN1; SMN2MAPTKDM4EADORA2A | |
| SCHEMBL28812702 | 0.78 | MAPT (0.48) | LMNASMN1; SMN2MAPTKDM4EADORA2A | |
| SCHEMBL2861970 | 0.78 | KDM4E (0.45) | LMNASMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL14334455 | 0.77 | MAPT (0.45) | LMNASMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL31305487 | 0.77 | LMNA (0.44) | LMNASMN1; SMN2MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001056995-A1 | SUBSTITUTED IMIDAZOLES AS SELECTIVE MODULATORS OF BRADYKININ B2 RECEPTORS | NUEROGEN CORPORATION (US) | 2001-08-09 | — | — | WO | disclosed |