Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.42 |
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993262 | 1.00 | MAPT (0.44) | MAPTAPPPTGS2CYP1A1PTGS1 | |
| SCHEMBL8346367 | 0.89 | MAPT (0.48) | MAPTAPPPTGS2CYP1A1PTGS1 | |
| SCHEMBL8346366 | 0.89 | MAPT (0.48) | MAPTAPPPTGS2CYP1A1PTGS1 | |
| SCHEMBL10479300 | 0.88 | APP (0.49) | MAPTAPPPTGS2CHEK1TTR | |
| SCHEMBL10479299 | 0.88 | APP (0.49) | MAPTAPPPTGS2CHEK1TTR | |
| SCHEMBL8346996 | 0.88 | TUBB4A (0.45) | MAPTAPPCYP1A1CHEK1CYP1B1 | |
| SCHEMBL8346999 | 0.88 | TUBB4A (0.45) | MAPTAPPCYP1A1CHEK1CYP1B1 | |
| SCHEMBL8343851 | 0.88 | CYP19A1 (0.52) | MAPTCHEK1KDM4EABCB1MEN1 | |
| SCHEMBL8343855 | 0.88 | CYP19A1 (0.52) | MAPTCHEK1KDM4EABCB1MEN1 | |
| SCHEMBL10479298 | 0.87 | CES2 (0.37) | MAPTAPPPTGS2CYP1A1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000020005-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING AN OPIATE ANALGESIC AND A SYNERGIZING SUBSTANCE | EGIS Gyógyszergyár Rt. (HU) | 2000-04-13 | — | — | WO | claimed |
| US-4840948-A | CARDIOTONIC AGENTS | EGIS GYOGYSZERGYAR (HU) | 1989-06-20 | — | — | US | claimed |
| WO-2000020005-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING AN OPIATE ANALGESIC AND A SYNERGIZING SUBSTANCE | EGIS Gyógyszergyár Rt. (HU) | 2000-04-13 | — | — | WO | disclosed |
| US-4840948-A | CARDIOTONIC AGENTS | EGIS GYOGYSZERGYAR (HU) | 1989-06-20 | — | — | US | disclosed |