Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.72 |
| ▸ | CA12 | O43570 | 3/20 | 0.68 |
| ▸ | CA1 | P00915 | 3/20 | 0.68 |
| ▸ | CA2 | P00918 | 3/20 | 0.68 |
| ▸ | CA9 | Q16790 | 3/20 | 0.68 |
| ▸ | CA4 | P22748 | 2/20 | 0.68 |
| ▸ | CA6 | P23280 | 2/20 | 0.68 |
| ▸ | CA5A | P35218 | 2/20 | 0.68 |
| ▸ | CA7 | P43166 | 2/20 | 0.68 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.68 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | PPARG | P37231 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.65 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.65 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24713415 | 0.93 | CA12 (0.68) | TP53CA12CA1CA2CA9 | |
| SCHEMBL23447443 | 0.90 | TP53 (0.56) | TP53CA12CA1CA2CA9 | |
| SCHEMBL1928662 | 0.88 | CA12 (0.85) | TP53CA12CA1CA2CA9 | |
| SCHEMBL6243996 | 0.88 | CA12 (0.85) | TP53CA12CA1CA2CA9 | |
| SCHEMBL23421176 | 0.88 | TP53 (0.63) | TP53CA12CA1CA2CA9 | |
| SCHEMBL6468377 | 0.87 | CA12 (0.70) | TP53CA12CA1CA2CA9 | |
| SCHEMBL9488026 | 0.86 | CNR2 (0.61) | TP53CA12CA1CA2CA9 | |
| SCHEMBL9486707 | 0.86 | MEN1 (0.65) | TP53CA12CA1CA2CA9 | |
| SCHEMBL9487208 | 0.85 | HRH3 (0.61) | TP53CA12CA1CA2CA9 | |
| SCHEMBL8764152 | 0.85 | EPHX2 (0.55) | TP53CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166615-B1 | IMPROVEMENTS IN OR RELATING TO BENZENESULFONAMIDO DERIVATIVES | ELI LILLY AND COMPANY (US) | 1993-05-26 | — | — | EP | claimed |
| US-5110830-A | Benzenesulfonamides treatment of tumors susceptible to | ELI LILLY AND COMPANY (US) | 1992-05-05 | — | — | US | claimed |
| US-4845128-A | ANTITUMOR | ELI LILLY AND COMPANY (US) | 1989-07-04 | — | — | US | claimed |
| EP-0166615-A2 | Improvements in or relating to benzenesulfonamido derivatives | ELI LILLY AND COMPANY (US) | 1986-01-02 | — | — | EP | claimed |
| CN-114761379-A | Color-developing agent and heat-sensitive recording material | 三菱化学株式会社 | 2022-07-15 | — | — | CN | disclosed |
| WO-2021107037-A1 | DEVELOPER AND THERMOSENSITIVE RECORDING MATERIAL | 三菱ケミカル株式会社 | 2021-06-03 | — | — | WO | disclosed |
| US-6281240-B1 | CYSTIC FIBROSIS | ELI LILLY AND COMPANY | 2001-08-28 | — | — | US | disclosed |
| WO-1998044799-A1 | DIARYLSULFONYLUREAS FOR USE IN TREATING SECRETORY DIARRHEA | ELI LILLY AND COMPANY (US) | 1998-10-15 | — | — | WO | disclosed |
| EP-0606723-A1 | Imidazolidin-2-one derivatives and their use as antitumor agents | ELI LILLY AND COMPANY (US) | 1994-07-20 | — | — | EP | disclosed |
| US-5270329-A | 1-arylsulfonyl-imidazolidin-2-one derivatives | ELI LILLY AND COMPANY (US) | 1993-12-14 | — | — | US | disclosed |
| US-5260338-A | Sulfonylureas | ELI LILLY AND COMPANY (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0166615-B1 | IMPROVEMENTS IN OR RELATING TO BENZENESULFONAMIDO DERIVATIVES | ELI LILLY AND COMPANY (US) | 1993-05-26 | — | — | EP | disclosed |
| US-5110830-A | Benzenesulfonamides treatment of tumors susceptible to | ELI LILLY AND COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-4845128-A | ANTITUMOR | ELI LILLY AND COMPANY (US) | 1989-07-04 | — | — | US | disclosed |
| EP-0166615-A2 | Improvements in or relating to benzenesulfonamido derivatives | ELI LILLY AND COMPANY (US) | 1986-01-02 | — | — | EP | disclosed |