Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.60 |
| ▸ | CA12 | O43570 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 2/20 | 0.58 |
| ▸ | CA9 | Q16790 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | IDH1 | O75874 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24713415 | 0.92 | CA12 (0.68) | MEN1KMT2AALDH1A1POLBEPHX2 | |
| SCHEMBL9487281 | 0.87 | CA1 (0.58) | MEN1KMT2AALDH1A1POLBEPHX2 | |
| SCHEMBL12010912 | 0.87 | NR1H3 (0.68) | MEN1KMT2AALDH1A1POLBEPHX2 | |
| SCHEMBL7993424 | 0.86 | TP53 (0.72) | MEN1KMT2APOLBEPHX2CA12 | |
| SCHEMBL9488026 | 0.86 | CNR2 (0.61) | MEN1KMT2AEPHX2CA12CA1 | |
| SCHEMBL29771100 | 0.85 | MAPT (0.69) | MEN1KMT2AALDH1A1POLBCA12 | |
| SCHEMBL23447667 | 0.85 | MAPT (0.69) | MEN1KMT2AALDH1A1POLBCA12 | |
| SCHEMBL4196236 | 0.84 | LMNA (0.78) | EPHX2CA12CA1CA2CA9 | |
| SCHEMBL3346579 | 0.84 | MAPT (0.68) | MEN1KMT2AALDH1A1POLBEPHX2 | |
| SCHEMBL12010881 | 0.83 | MEN1 (0.68) | MEN1KMT2AALDH1A1POLBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260338-A | Sulfonylureas | ELI LILLY AND COMPANY (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0166615-B1 | IMPROVEMENTS IN OR RELATING TO BENZENESULFONAMIDO DERIVATIVES | ELI LILLY AND COMPANY (US) | 1993-05-26 | — | — | EP | disclosed |
| US-5110830-A | Benzenesulfonamides treatment of tumors susceptible to | ELI LILLY AND COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-4845128-A | ANTITUMOR | ELI LILLY AND COMPANY (US) | 1989-07-04 | — | — | US | disclosed |
| US-4845128-A | ANTITUMOR | ELI LILLY AND COMPANY (US) | 1989-07-04 | — | — | US | disclosed |
| EP-0166615-A2 | Improvements in or relating to benzenesulfonamido derivatives | ELI LILLY AND COMPANY (US) | 1986-01-02 | — | — | EP | disclosed |