Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | IDH1 | O75874 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.54 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24713415 | 0.86 | CA12 (0.68) | EPHX2MAPTCA12CA1CA2 | |
| SCHEMBL7993424 | 0.85 | TP53 (0.72) | EPHX2MAPTCA12CA1CA2 | |
| SCHEMBL8762900 | 0.82 | CA12 (0.57) | IDH1CA12CA1CA2CA9 | |
| SCHEMBL8762784 | 0.82 | MEN1 (0.53) | IDH1CA12CA1CA2CA9 | |
| SCHEMBL9486707 | 0.82 | MEN1 (0.65) | EPHX2IDH1MAPTCA12CA1 | |
| SCHEMBL9487281 | 0.81 | CA1 (0.58) | EPHX2MAPTCA12CA1CA2 | |
| SCHEMBL9488026 | 0.80 | CNR2 (0.61) | EPHX2IDH1MAPTCA12CA1 | |
| SCHEMBL9485863 | 0.79 | CA1 (0.56) | EPHX2IDH1MAPTCA12CA1 | |
| SCHEMBL9487208 | 0.79 | HRH3 (0.61) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL4005055 | 0.78 | IDO1 (0.65) | EPHX2IDH1MAPTCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550157-B1 | Antitumor compositions and methods of treatment | LILLY CO ELI (US) | 1997-07-23 | — | — | EP | claimed |
| US-5354778-A | N-Phenyl-N'-substituted phenylsulfonylureas | ELI LILLY AND COMPANY (US) | 1994-10-11 | — | — | US | claimed |
| EP-0550157-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-07-07 | — | — | EP | claimed |
| EP-0550157-B1 | Antitumor compositions and methods of treatment | LILLY CO ELI (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5354778-A | N-Phenyl-N'-substituted phenylsulfonylureas | ELI LILLY AND COMPANY (US) | 1994-10-11 | — | — | US | disclosed |
| US-5234955-A | N-phenyl-N*-substituted phenylsulfonylureas | ELI LILLY AND COMPANY (US) | 1993-08-10 | — | — | US | disclosed |
| EP-0550157-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-07-07 | — | — | EP | disclosed |