SCHEMBL7993430

SCHEMBL7993430

c1ccc2c(C3CNCCN3)csc2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 2/20 0.40
DRD2 P14416 1/20 0.39
CYP2A6 P11509 3/20 0.39
MAPT P10636 1/20 0.38
CHRNA7 P36544 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.34
CRHBP P24387 1/20 0.34
CRHR2 Q13324 1/20 0.34
CHRM2 P08172 2/20 0.33
CHRM4 P08173 2/20 0.33
CHRM5 P08912 2/20 0.33
CHRM1 P11229 2/20 0.33
CHRM3 P20309 2/20 0.33
MTNR1A P48039 1/20 0.32
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
HDAC3 O15379 1/20 0.31
HDAC4 P56524 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC7 Q8WUI4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28502662 0.81 SLC6A4 (0.43) SLC6A4DRD2CYP2A6MAPTCHRNA7
SCHEMBL7997129 0.81 HTR2A (0.36) SLC6A4CYP2A6SMN1; SMN2CA1CA2
SCHEMBL7993389 0.81 MAPT (0.36) DRD2MAPTCA1CA2
SCHEMBL24364984 0.79 SLC6A4 (0.43) SLC6A4DRD2CYP2A6CHRNA7SMN1; SMN2
SCHEMBL8668179 0.77 SLC6A4 (0.40) SLC6A4DRD2CYP2A6MAPTCHRNA7
SCHEMBL8671659 0.77 SLC6A4 (0.40) SLC6A4DRD2CYP2A6MAPTCHRNA7
Hydrochloric Acid SCHEMBL2957745 0.76 HTR2C (0.39) CA1CA2
SCHEMBL30469977 0.73 SLC6A4 (0.43) SLC6A4DRD2CYP2A6MAPTCHRNA7
SCHEMBL29324945 0.73 SLC6A4 (0.43) SLC6A4DRD2CYP2A6MAPTCHRNA7
SCHEMBL24364676 0.73 SLC6A4 (0.43) SLC6A4DRD2CYP2A6MAPTCHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5210193-A Bactericide AMERICAN CYANAMID COMPANY (US) 1993-05-11 US claimed
EP-0230053-A2 7-(Substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids AMERICAN CYANAMID COMPANY (US) 1987-07-29 EP claimed
US-6284775-B1 PSYCHOLOGICAL DISORDERS AVENTIS PHARMACEUTICALS INC. 2001-09-04 US disclosed
US-5801186-A ANTIPSYCHOTIC AGENTS HOECHST MARION ROUSSEL, INC. (US) 1998-09-01 US disclosed
US-5371087-A Antipsychotic, analgesics, anticonvulsant and anxiolytic agent HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1994-12-06 US disclosed
US-5229388-A 3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone and related compounds HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1993-07-20 US disclosed
US-5136037-A 3-(4-substituted-4-piperazinyl)butyl-4-thiazolidinone and related compounds HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1992-08-04 US disclosed
US-5037984-A Anticonvulsants; anxiolytic agents HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1991-08-06 US disclosed
US-4933453-A ANTIPSYCHOTIC, ANALGESIC, ANTICONVULSANT, AND ANXIOLYTIC AGENTS HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1990-06-12 US disclosed