Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.68 |
| ▸ | CHEK2 | O96017 | 10/20 | 0.67 |
| ▸ | MMP2 | P08253 | 1/20 | 0.66 |
| ▸ | MMP9 | P14780 | 1/20 | 0.66 |
| ▸ | MMP8 | P22894 | 1/20 | 0.66 |
| ▸ | MMP13 | P45452 | 1/20 | 0.66 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.57 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.57 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993467 | 0.90 | MPL (0.61) | MPLHDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL20982511 | 0.84 | MMP2 (0.78) | MPLHDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL5219768 | 0.84 | NR4A2 (0.83) | MPLHDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL12824938 | 0.83 | NPC1 (0.63) | HDAC3HDAC1HDAC8HDAC6CHEK2 | |
| SCHEMBL3546177 | 0.83 | MPL (1.00) | MPLHDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL20982644 | 0.83 | NR4A2 (0.86) | HDAC3HDAC1HDAC8HDAC6CHEK2 | |
| SCHEMBL7943528 | 0.82 | MMP2 (0.71) | MPLCHEK2MMP2MMP9MMP8 | |
| SCHEMBL18229540 | 0.81 | HDAC6 (1.00) | HDAC3HDAC1HDAC8HDAC6CHEK2 | |
| SCHEMBL3567770 | 0.81 | CHEK2 (0.66) | MPLHDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL3569187 | 0.81 | CHEK2 (0.66) | MPLHDAC3HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010024833-A1 | Methods for the solid phase synthesis of combinatorial libraries of benzimidazol, benzoxazoles, benzothiazoles, and derivatives thereof | LABORDE EDGARDO (US) | 2001-09-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010024833-A1 | Methods for the solid phase synthesis of combinatorial libraries of benzimidazol, benzoxazoles, benzothiazoles, and derivatives thereof | EIF2AK2, CDK15, CDK17 | MPL 2107/4885HDAC3 155/4885HDAC1 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.