Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975974 | 0.93 | MAPK9 (0.49) | NPC1RAB9AHPGDSMN1; SMN2MAPK9 | |
| SCHEMBL7987483 | 0.81 | MAPK9 (0.49) | NPC1RAB9AHPGDTP53NFKB1 | |
| SCHEMBL7976824 | 0.81 | HPGD (0.46) | NPC1RAB9AHPGDTP53NFKB1 | |
| SCHEMBL7993759 | 0.80 | MME (0.52) | HPGDKDM4ETDP1HTTTSHR | |
| SCHEMBL7975878 | 0.79 | TRPM8 (0.44) | NPC1RAB9AHPGDTP53NFKB1 | |
| SCHEMBL7990464 | 0.78 | MAPK9 (0.54) | NPC1RAB9AHPGDSMN1; SMN2MAPK9 | |
| SCHEMBL7975874 | 0.77 | RXFP1 (0.44) | NPC1RAB9AHPGDTP53NFKB1 | |
| SCHEMBL7990600 | 0.76 | SLC6A2 (0.43) | NPC1RAB9AHPGDSMN1; SMN2KDM4E | |
| SCHEMBL11161417 | 0.76 | MAPK9 (0.51) | HPGDMAPK9PTGS1PTGS2KMT2A | |
| SCHEMBL7987498 | 0.75 | RAB9A (0.48) | NPC1RAB9AHPGDKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |