Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NQO1 | P15559 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.45 |
| ▸ | TUBB | P07437 | 2/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986890 | 0.84 | EDNRA (0.52) | KMT2AMAPTTP53ALDH1A1MAPK1 | |
| SCHEMBL7990464 | 0.83 | MAPK9 (0.54) | KMT2AALDH1A1MAPK1CYP3A4 | |
| SCHEMBL3621060 | 0.82 | CYP3A4 (0.53) | KMT2AMAPTTP53ALDH1A1MAPK1 | |
| SCHEMBL7987077 | 0.79 | NPC1 (0.55) | KMT2AMAPTALDH1A1MAPK1KDM4E | |
| SCHEMBL7987319 | 0.79 | MAPK1 (0.50) | KMT2AALDH1A1MAPK1KDM4ECYP3A4 | |
| SCHEMBL3625103 | 0.78 | CYP3A4 (0.51) | KMT2AMAPTTP53ALDH1A1MAPK1 | |
| SCHEMBL7989760 | 0.77 | ALDH1A1 (0.59) | KMT2AMAPTALDH1A1MAPK1CYP3A4 | |
| SCHEMBL3621067 | 0.77 | CYP3A4 (0.50) | KMT2AMAPTTP53ALDH1A1MAPK1 | |
| SCHEMBL7976622 | 0.76 | MAPK9 (0.47) | KMT2AALDH1A1MAPK1KDM4ECYP3A4 | |
| SCHEMBL7976072 | 0.75 | MAPK9 (0.52) | KMT2AALDH1A1MAPK1KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |