Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2877032 | 0.82 | GBA1 (0.57) | GBA1HDAC1HDAC8HDAC6EGFR | |
| SCHEMBL13917941 | 0.81 | GBA1 (0.50) | GBA1HDAC1HDAC8HDAC6EGFR | |
| SCHEMBL28861327 | 0.78 | HDAC1 (0.50) | GBA1HDAC1HDAC8HDAC6EGFR | |
| SCHEMBL30358562 | 0.78 | CA12 (0.57) | GBA1HDAC1HDAC8HDAC6HPGD | |
| SCHEMBL9956587 | 0.78 | CA12 (0.57) | GBA1HDAC1HDAC8HDAC6HPGD | |
| SCHEMBL9385027 | 0.77 | HDAC8 (0.47) | GBA1HDAC1HDAC8HDAC6HPGD | |
| SCHEMBL10055049 | 0.77 | ALDH1A1 (0.55) | GBA1HDAC1HDAC8HDAC6HPGD | |
| SCHEMBL13098114 | 0.76 | HSD17B10 (0.47) | HDAC1HDAC8HDAC6HPGDKMT2A | |
| SCHEMBL505777 | 0.74 | CA1 (0.50) | HPGDTP53MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL9537223 | 0.74 | MAPT (0.58) | HDAC1HDAC8HDAC6EGFRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001044184-A1 | SYNTHESIS OF INDOLE-CONTAINING SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-06-21 | — | — | WO | disclosed |