Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.58 |
| ▸ | MEN1 | O00255 | 8/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.58 |
| ▸ | CRHBP | P24387 | 4/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10549460 | 0.89 | MAPT (0.51) | MAPTMEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL3857819 | 0.86 | PPIA (0.49) | MAPTMEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL31210058 | 0.84 | MAPT (0.57) | MAPTMEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL26654780 | 0.82 | MAPT (0.47) | MAPTMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL10842868 | 0.81 | MAPT (0.60) | MAPTMEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL2877032 | 0.80 | GBA1 (0.57) | MAPTMEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL3857097 | 0.79 | MAPT (0.49) | MAPTMEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL21685528 | 0.79 | HSPB1 (0.49) | MAPTMEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL9537183 | 0.79 | ALDH1A1 (0.55) | MAPTMEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL9537129 | 0.79 | MAPT (0.60) | MAPTMEN1KMT2ACRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |