Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.66 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ELANE | P08246 | 4/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987656 | 1.00 | LTB4R (0.66) | LTB4RLTB4R2NPC1HPGDRAB9A | |
| SCHEMBL3123036 | 0.93 | MAOB (0.64) | LTB4RLTB4R2NPC1HPGDRAB9A | |
| SCHEMBL8637573 | 0.88 | KMT2A (0.60) | LTB4RLTB4R2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9236564 | 0.86 | SMPD1 (0.73) | NPC1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL31025721 | 0.86 | NPC1 (0.75) | NPC1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL340620 | 0.86 | NPC1 (0.75) | NPC1HPGDRAB9ASMN1; SMN2MAOB | |
| SCHEMBL6812967 | 0.85 | NPC1 (0.59) | LTB4RLTB4R2NPC1HPGDRAB9A | |
| SCHEMBL16471662 | 0.83 | NPC1 (0.53) | LTB4RLTB4R2NPC1HPGDRAB9A | |
| SCHEMBL12526571 | 0.83 | SMPD1 (0.58) | LTB4RLTB4R2NPC1HPGDRAB9A | |
| SCHEMBL4939800 | 0.82 | NPC1 (0.62) | NPC1HPGDRAB9ASMN1; SMN2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291530-B1 | Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity | NOVARTIS AG (CH) | 2001-09-18 | — | — | US | disclosed |
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |