Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870656 | 0.86 | MAPT (0.56) | MAPTNPC1RAB9ASMN1; SMN2ATM | |
| SCHEMBL2908895 | 0.80 | MAPT (0.62) | MAPTNPC1RAB9ASMN1; SMN2ATM | |
| SCHEMBL11769542 | 0.79 | POLB (0.77) | MAPTNPC1RAB9ASMN1; SMN2ATM | |
| SCHEMBL30288146 | 0.79 | POLB (0.77) | MAPTNPC1RAB9ASMN1; SMN2ATM | |
| SCHEMBL7996943 | 0.78 | SMN1; SMN2 (0.60) | MAPTNPC1RAB9ASMN1; SMN2ATM | |
| SCHEMBL6482600 | 0.78 | MAPK14 (0.56) | MAPTNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL15676741 | 0.77 | POLB (0.64) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL4833664 | 0.76 | HTT (0.62) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL2560246 | 0.76 | MAPT (0.55) | MAPTNPC1RAB9ASMN1; SMN2ATM | |
| SCHEMBL246858 | 0.76 | SLC7A5 (0.59) | SMN1; SMN2KMT2AMEN1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817629-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-03-08 | — | — | EP | disclosed |
| EP-0817629-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5631280-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1996030014-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-10-03 | — | — | WO | disclosed |