Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21870336 | 0.89 | POLB (0.68) | SMN1; SMN2HSD17B10NPSR1MAPTNPC1 | |
| SCHEMBL2908895 | 0.84 | MAPT (0.62) | SMN1; SMN2HSD17B10MAPTNPC1RAB9A | |
| SCHEMBL17744840 | 0.84 | SMN1; SMN2 (0.71) | SMN1; SMN2HSD17B10NPSR1MAPTNPC1 | |
| SCHEMBL9789598 | 0.83 | ALDH1A1 (0.68) | SMN1; SMN2HSD17B10NPSR1MAPTNPC1 | |
| SCHEMBL30288146 | 0.82 | POLB (0.77) | SMN1; SMN2HSD17B10MAPTNPC1RAB9A | |
| SCHEMBL11769542 | 0.82 | POLB (0.77) | SMN1; SMN2HSD17B10MAPTNPC1RAB9A | |
| SCHEMBL8870656 | 0.81 | MAPT (0.56) | SMN1; SMN2MAPTNPC1RAB9AMEN1 | |
| SCHEMBL16274153 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2HSD17B10NPSR1MAPTNPC1 | |
| SCHEMBL8522632 | 0.80 | HDAC1 (0.72) | SMN1; SMN2HSD17B10NPSR1MAPTNPC1 | |
| SCHEMBL2560246 | 0.79 | MAPT (0.55) | SMN1; SMN2HSD17B10MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817629-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-03-08 | — | — | EP | disclosed |
| EP-0817629-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5631280-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1996030014-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-10-03 | — | — | WO | disclosed |