Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963583 | 0.93 | — | — | |
| SCHEMBL4963577 | 0.93 | — | — | |
| SCHEMBL13533918 | 0.93 | — | — | |
| SCHEMBL7993708 | 0.83 | — | — | |
| SCHEMBL2399501 | 0.82 | ACE (0.42) | MAPTSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL8560270 | 0.80 | ALDH1A1 (0.42) | MAPTSMN1; SMN2ALDH1A1EPHX1CA12 | |
| SCHEMBL11547875 | 0.77 | EPHX1 (0.35) | SMN1; SMN2ALDH1A1EPHX1CA12CA1 | |
| SCHEMBL23644003 | 0.77 | ALDH1A1 (0.42) | MAPTSMN1; SMN2ALDH1A1HTTTSHR | |
| SCHEMBL16200561 | 0.77 | MAPT (0.40) | MAPTSMN1; SMN2ALDH1A1CA12CA1 | |
| SCHEMBL2557179 | 0.76 | CYP3A4 (0.39) | SMN1; SMN2EPHX1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009146182-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-03 | — | — | WO | disclosed |