Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8003565 | 0.87 | KDM4E (0.41) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7993555 | 0.80 | PDE3B (0.39) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL7993028 | 0.80 | KDM4E (0.38) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL12362342 | 0.80 | KDM4E (0.41) | KDM4EALDH1A1HPGDTSHRHBB | |
| SCHEMBL8005279 | 0.80 | MEN1 (0.36) | KDM4EALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL8006158 | 0.79 | IGF1R (0.35) | MEN1KMT2AMAPTNPC1PTGS1 | |
| SCHEMBL577700 | 0.78 | KMT2A (0.40) | KDM4EALDH1A1HPGDL3MBTL1CYP1A2 | |
| SCHEMBL8006684 | 0.77 | NPC1 (0.37) | KDM4EALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL7996053 | 0.76 | KDM4E (0.36) | KDM4EALDH1A1L3MBTL1MAPTNPSR1 | |
| SCHEMBL11904911 | 0.75 | CYP1B1 (0.40) | KDM4EALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009099596-A2 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARAMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |