Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FER | P16591 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994718 | 0.87 | KDM4E (0.40) | KDM4EMEN1KMT2AACHEALDH1A1 | |
| SCHEMBL8005879 | 0.81 | KDM4E (0.42) | KDM4EMEN1KMT2AACHEALDH1A1 | |
| SCHEMBL15216084 | 0.80 | ACHE (0.40) | KDM4EMEN1KMT2AACHEALDH1A1 | |
| SCHEMBL8005887 | 0.80 | SLC2A1 (0.40) | KDM4EALDH1A1SMN1; SMN2KDRNPC1 | |
| SCHEMBL15216086 | 0.80 | PDE4B (0.35) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL15216081 | 0.78 | KDM4E (0.35) | KDM4EMEN1KMT2AACHEALDH1A1 | |
| SCHEMBL7996051 | 0.77 | KMT2A (0.37) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL577700 | 0.77 | KMT2A (0.40) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8003756 | 0.76 | KDM4E (0.36) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7996056 | 0.76 | SLC2A1 (0.35) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250174-B1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS INC (US) | 2013-08-28 | — | — | EP | disclosed |
| WO-2009099596-A2 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARAMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |