SCHEMBL7994742

SCHEMBL7994742

CCOC(=O)Cc1cc2c(n1C(=O)OCc1ccccc1)CCN(C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NCc1ccc(C(=NC(=O)OC(C)(C)C)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1)C2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGA4 P13612 3/20 0.36
ITGB7 P26010 3/20 0.36
ADORA1 P30542 1/20 0.34
P2RX7 Q99572 7/20 0.34
ITGB3 P05106 1/20 0.32
ITGA2B P08514 1/20 0.32
HTR1A P08908 1/20 0.32
CHRM5 P08912 1/20 0.32
SLC6A2 P23975 1/20 0.32
HRH2 P25021 1/20 0.32
ADRA1D P25100 1/20 0.32
HTR1B P28222 1/20 0.32
HTR2A P28223 1/20 0.32
HTR2C P28335 1/20 0.32
HTR1E P28566 1/20 0.32
HRH1 P35367 1/20 0.32
HTR2B P41595 1/20 0.32
SLC6A3 Q01959 1/20 0.32
TMEM97 Q5BJF2 1/20 0.32
SIGMAR1 Q99720 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7989512 0.94 ITGB3 (0.38) ADORA1P2RX7ITGB3ITGA2BHCRTR2
SCHEMBL7992731 0.85 ITGA4 (0.38) ITGA4ITGB7ADORA1P2RX7ITGB3
SCHEMBL7987546 0.84 ADORA1 (0.47) ITGA4ITGB7ADORA1P2RX7HCRTR2
SCHEMBL7989036 0.83 ADORA1 (0.35) ITGA4ITGB7ADORA1ITGB3ITGA2B
SCHEMBL7994609 0.82 ITGB3 (0.37) ITGA4ITGB7ADORA1ITGB3ITGA2B
SCHEMBL8156014 0.79 ITGB3 (0.38) ITGA4ITGB7ADORA1ITGB3ITGA2B
SCHEMBL7992291 0.79 ITGB3 (0.40) ADORA1P2RX7ITGB3ITGA2BHCRTR2
SCHEMBL7986784 0.79 ITGB3 (0.37) ITGA4ITGB7ADORA1ITGB3ITGA2B
Trifluoroacetic Acid SCHEMBL7974839 0.78 ITGB3 (0.51) ADORA1P2RX7ITGB3ITGA2BHCRTR2
SCHEMBL7993666 0.77 ITGB3 (0.37) ITGA4ITGB7ADORA1ITGB3ITGA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6265418-B1 ANTICOAGULANTS UBE INDUSTRIES, LTD. (JP) 2001-07-24 US disclosed
EP-1020467-A1 N-ACYLAMINO ACID AMIDE COMPOUNDS AND INTERMEDIATES FOR PREPARATION THEREOF UBE INDUSTRIES LIMITED (JP) 2000-07-19 EP disclosed